Studies by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) have demonstrated that common alleles in RAD51, FGFR2, MAP3K1, TOX3/TNRC9, LSP1, SLC4A7/NEK10, a 2q35 locus and a 5p12 locus affect breast cancer risk in BRCA2 mutation carriers [18-20]. The gene discussed is BRCA1; the disease is breast cancer.