We measured the expression level of IGFBP5, SPP1, RRM2, BIRC5, MUC16 and PAX8 by quantitative real-time PCR and of all eleven genes using Illumina HT12 v3 expression microarrays in the normal breast tissue of healthy controls, in the normal breast tissue of breast cancer patients (non-carriers of BRCA2 germline mutations) and also in blood from healthy controls. This evidence concerns the gene SPP1 and breast cancer.