The risk was significantly higher compared with that among patients who had ever smoked but did not carry these genotypes (for TGFB1+868 SNP in relation to IHD; smoke+/TC+ versus smoke+/TC-, OR = 2.57, 95% CI 1.48 to 4.47, P = 0.007; in relation to MI, OR = 2.42, 95% CI 1.26 to 4.67, P = 0.007). The gene discussed is TGFB1; the disease is myocardial ischemia.