Independent risk factors significantly associated with IHD included TGFB1+868 TC-smoking interaction, older age, male sex, CRP of at least 10 mg/L, hypercholesterolemia, and diabetes, whereas those associated with MI were TGFB1+868 TC-smoking interaction, male sex, CRP of at least 10 mg/L, RF+ (borderline association), hypertension, and hypercholesterolemia. This evidence concerns the gene CRP and familial hypercholesterolemia.