We observed a downregulation in the expression of the miRNAs targeting Akt2, CBL, E2F2, E2F3, Cyclin Dl, K-ras, PIK3R1, SOS1 and TGFβR2 in CML cell lines and patients as compared to healthy blood. This evidence concerns the gene PIK3R1 and chronic myelogenous leukemia, BCR-ABL1 positive.