BRCA1 and metastatic neoplasm: The data showed that BRCA1-IRIS is expressed at very low level in normal breast tissues (Figure 1H and arrow in 1I), at moderate level in DCIS tumors (Figure 1J and see BRCA1-positive [solid arrow] vs. -negative [dashed arrow] in Figure 1K), and at very high level in invasive (Figure 1L and arrow in 1M) and metastatic tumors (not shown).