We found that one primary MYC IHC-High DLBCL case (Case #8) had copy number gain in MYC (6 copies), however the remaining cases had only 2 copies of MYC. Alternative cellular alterations resulting in increased MYC expression have been described for tumors other than DLBCL, and these include transcriptional and post-transcriptional deregulation [18], [19]. Here, MYC is linked to diffuse large B-cell lymphoma.