Studies have demonstrated, in particular, that modulation of Grm3 decreases ethanol seeking in rats [77], [78]; although the agonists used in these studies also bind Grm2. Grm3 is also a high priority candidate gene for schizophrenia, as a group II mGluR agonist (LY354740) blocked many symptoms induced in the rat phencyclidine treatment model of schizophrenia [79]. This evidence concerns the gene GRM2 and schizophrenia.