Among the most highly connected hubs within ErGeN3 were a number of genes that have been previously implicated in modulating level of response to ethanol or susceptibility to alcohol dependence (Figure 6), including Kcnma1 and Gsk3β. Kcnma1 is a large conductance potassium channel whose activity is directly affected by ethanol [49]. Here, KCNMA1 is linked to alcohol dependence.