In total, we identified 12 independent cross-ethnic risk alleles increasing T2D risk, including one in SLC30A8, IGF2BP2, KCNJ11, FTO, and two in TCF7L2 (R2 = 0.512), two in CDKAL1 (R2 = 0.677), two in KCNQ1 (R2 = 0.425), and two outside gene regions. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.