HSP90AA1 and breast cancer: We observed that 8% of breast cancer samples carried amplifications (both high-level and low-level amplifications, CN ≥3) of HSP90AA1, leading to a higher expression of HSP90AA1, compared with samples without HSP90AA1 amplifications (P = 7.67 × 10-8, n = 481, Mann-Whitney U Test; Figure 3A).