We found that up-regulated HSP90 was significantly associated with a higher risk of death from breast cancer (P = 0.0049, n = 395, Figure 3B) and poor overall survival in a subset of 1,027 patients in which overall survival data were available (P = 0.0034, log-rank Mantel-cox test, Figure 3C). This evidence concerns the gene HSP90AA1 and breast cancer.