In breast cancer, HSP90 is required for the stabilization of many proteins in pathways that play key roles in cancer growth and survival, such as estrogen receptor (ER), progesterone receptor (PR), essential components of HER2 signaling (HER2, AKT, c-SRC, RAF and HIF-1α), and EGFR [9,13]. This evidence concerns the gene ESR1 and breast carcinoma.