Our results suggest that up-regulated HSP90 might not be an independent poor prognosis factor among patients with HER2-positive breast cancer, as no statistically significant correlation was observed between poor survival and high-level expression of any HSP90 isoforms, which is consistent with the previous finding that the most common clinical response in patients with HER2-positive breast cancer who received HSP90 monotherapy is stable disease. This evidence concerns the gene ERBB2 and breast carcinoma.