ESR1 and breast carcinoma: To investigate the correlation of up-regulated HSP90 and poor breast cancer prognosis, we performed a univariate Kaplan-Meier survival analysis and a multivariate Cox Proportional-Hazards Regression (COXPH) survival analysis using other poor clinical outcome-associated clinical cofactors, such as tumor size, grade, nodal status, age, HER2, ER and PRstatus, as co-variants.