For example, Chen et al. [19] in 2007 found that SOX4 gene mutation is significantly associated with pathological stages and the mutation rate increases gradually, which has relation with advanced pathological stages in non-small cell lung cancer tissues, suggesting that the SOX4 gene mutations might be related in the lung carcinogenesis and tumor metastasis. The gene discussed is SOX4; the disease is non-small cell lung carcinoma.