SOX4 and neoplasm: Firstly, the SOX4 protein was up-regulated in tumor cells of PGC tissues, but not expressed in normal epithelium of gallbladder; Secondly, the decreased SOX4 expression in PGC tissues was significantly correlated with advanced tumor progression and aggressive clinicopathological features; Thirdly, the results of Kaplan-Meier analyses shown that PGC tissues with strong SOX4 expression tend to have increased OS and DFS rates respectively.