As shown in Figures 2B and 2C, only the TC-1 tumor cells treated with NKG2D-Fc-GLuc demonstrated significant luciferase activity, when compared to TC-1 tumor cells incubated with the Con-Fc-GLuc, NKG2D-Fc, or Con-Fc, or with no treatment. The gene discussed is KLRK1; the disease is neoplasm.