In order to determine if (1) mice could be injected intramuscularly with the DNA construct encoding NKG2D-Fc-IL2 and successfully produce detectable amounts of the chimeric protein and (2) the protein was capable of targeting NKG2D ligand-expressing tumor cells in vivo, TC-1 tumor-bearing mice were intramuscularly injected with DNA constructs encoding NKG2D-Fc-IL2, NKG2D-Fc, Con-Fc-IL2, Con-Fc, or no protein, followed by electroporation. The gene discussed is IL2; the disease is neoplasm.