Prior research has reported that polymorphic variations in promoter regions of the NF-κB1 gene NFKB1 and the IκBα gene NFKBIA and in the 3′-untranslated region (3′-UTR) of NFKBIA were associated with a risk for Hodgkin's lymphoma, multiple myeloma, breast cancer, prostate cancer, gastric cancer, colorectal cancer, and melanoma [17]–[23]. This evidence concerns the gene NFKB1 and colorectal cancer.