LAPTM4B genotype (RR, 2.729, 95%CI, 1.427–5.220, P = 0.002) and portal vein invasion (RR, 2.953, 95%CI, 1.437–6.068, P = 0.003) are also independent prognostic markers for disease-free survival of patients with HCC (Table 3; P<0.05). Here, LAPTM4B is linked to hepatocellular carcinoma.