Multivariate Cox regression analysis revealed that LAPTM4B genotype (RR, 3.147, 95%CI, 1.619–6.115, P = 0.001) and portal vein invasion (RR, 3.542, 95%CI, 1.752–7.158, P<0.001) are independent prognostic markers for overall survival of patients with HCC (Table 3; P<0.05). This evidence concerns the gene LAPTM4B and hepatocellular carcinoma.