As reported in our previous study, we found that the allelic frequencies of the LAPTM4B*2 allele were 38.24% in the HCC group and 24.07% in the control group, representing a significant different between these two groups (P<0.001), and suggesting that the LAPTM4B*2 allele is associated with significantly increased risk of hepatocellular carcinoma [23]. This evidence concerns the gene LAPTM4B and hepatocellular carcinoma.