The purpose of the current study was to: 1) investigate associations between chemerin and MetS diagnostic parameters, and serum levels of inflammatory and anti-inflammatory markers including high sensitivity C- reactive protein (hsCRP), pentraxin 3 (PTX3), and adiponectin; and 2) determine whether serum chemerin is a novel predictive marker for MetS in overweight and obese Korean adults. This evidence concerns the gene RARRES2 and metabolic syndrome.