INS and obesity due to melanocortin 4 receptor deficiency: The observation of increased FFAs with high glucose in the absence of insulin, a condition not usually seen in-vivo, nonetheless brings attention to the fact that hyperglycaemia, in the absence of adequate insulin, can contribute to high circulating FFAs, which are associated with other morbidities such as obesity [38], cardiopathy [39], and atherothrombosis [40].