To investigate whether the beneficial effects of NSC61610 in IBD required expression of PPAR γ in T cells or macrophages, wild-type (PPAR γ fl/fl, Cre-) mice, macrophage-specific PPAR γ null mice (PPAR γ fl/fl; lysozyme M-Cre+) and T cell-specific PPAR γ null mice (PPAR γ fl/fl; CD4-Cre+) were challenged with 2.5% DSS in the drinking water for 6 days, and disease activity was monitored daily. The gene discussed is LYZ; the disease is inflammatory bowel disease.