The cytoxicity of all three RLIP76 targeting agents, RLIP76 siRNA, antibody and antisense, was preferentially directed towards the malignant cells as compared with the non-malignant HUVEC cells, which was similar to our observations with other malignant (lung, melanoma, kidney, prostate) and non-malignant cell lines [22], [24], [29], [34]. This evidence concerns the gene RALBP1 and melanoma.