Loss of E-cadherin alters the natures of cell contacts and given the highly metastatic and aggressive nature of pancreatic cancer, the over-expression of E-cadherin following RLIP76 depletion is a salient factor as it is a marker which distinguishes noncohesive pancreatic cancers from cohesive pancreatic cancers [49], [50]. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.