Depletion of RLIP76 by antisense significantly increased the levels of the pro-differentiation marker E-cadherin and pro-apoptotic protein Bim while decreasing the levels of anti-apoptotic protein Bcl2, cyclin B1 and CDK4 in both BxPC3 and Panc-1 pancreatic cancer cells. Here, BCL2 is linked to familial pancreatic carcinoma.