Polymorphisms both in the regulatory and coding region of the IL-12Rβ2 gene have been identified in leprosy, (−1047delT, −1035A/G, −1033T>C,–1023A/G, −650delG, −568A/C, −557T/C, −550T/C, −464A/G −464A/C, 202T/C and−188A/C, [16] and in allergic, respiratory disorders such as asthma, (−1035A/G, −1033T/C, −1023A/G, −465A/G and −237C/T, [10]. This evidence concerns the gene IL12RB2 and asthma.