For example, both A549 and UT-SCC15 showed distinctive basal patterns of genes encoding for proteins with functions in the modulation of the ECM like Laminin, Fibronectin, Collagen, a finding similarly observed in a basal gene expression analysis of 60 cancer cell lines and their corresponding cancer tissues and in a study done on melanoma [30], [42]. The gene discussed is FN1; the disease is cancer.