The strong association between HLA-DRB1-DQB1 loci and MS has been established across many populations, with consistent findings indicating that predisposition is carried by the *15:01-* 06:02 haplotype in all populations of North-European ancestry [4], while in Israel [11] and in Mediterranean [8]–[10] populations, predisposition to the disease is carried by different DRB1* variants. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.