Through a systematic review, we identified 22 articles reporting the genetic associations of 11 genes with PCV and AMD, including LOC387715, HTRA1, CFH, CFB, C2, SERPING1, elastin, SOD2, PEDF, TLR3, and 9p21. Among them, only LOC387715rs10490924 was statistically different between PCV and AMD, with an allelic OR of 0.66 (95% CI: 0.57–0.76, p<0.00001). This evidence concerns the gene C2 and age-related macular degeneration.