In summary, we conducted a meta- and gene-based analysis of the association of POAG with genetic polymorphisms in CYP1B1. We did not detect any SNP showing significant association with POAG, and the gene-based analysis indicated that, based on current evidence from published studies, the cumulative effect of polymorphisms in CYP1B1 is not significantly associated with POAG. Here, CYP1B1 is linked to open-angle glaucoma.