CAV1 and open-angle glaucoma: Recent genome-wide association studies of primary open angle glaucoma have begun to identify genetic factors that each contribute small risk for disease, including caveolin 1 and 2 (CAV1/CAV2) [18] cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) [19], and transmembrane and coiled-coil domains 1 (TMCO1) [19].