CYP1B1 and Axenfeld-Rieger syndrome: Similarly, genes have been discovered that cause primary congenital glaucoma (PCG), cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) [9] and latent transforming growth factor beta binding protein 1 (LTBP2) [10], and Axenfeld-Rieger syndrome, paired-like homeodomain 2 (PITX2) [11] and forkhead box C1 (FOXC1) [12,13].