Although Cdkn1a is generally known as a member of the p53-dependent damage response pathway [54], this gene has also been found to play a role in development in which Cdkn1a is expressed in differentiating melanocytes [55] as well as acting as a positive cofactor of microphthalmia-associated transcription factor expression in melanoma cells [56]. This evidence concerns the gene CDKN1A and melanoma.