CLEC7A and colitis: Since dectin-1 is expressed in the myeloid compartment of the mouse intestine and is up-regulated during colitis (Figure 1A and 1B) and the lack of dectin-1 leads to reduced production of TNF-α and IL-10 production by macrophages we hypothesised that dectin-1 deficient mice would develop less inflammation after inducing DSS colitis.