Other researchers have reported associations of RNF11 with glutathione S-transferase -tagged Itch in breast cancer cell lines [21], tagged RNF11 with tagged TAX1BP1 and A20 in HEK cells [19] and RNF11 with A20, TAX1BP1 and RIP1 in mouse embryonic fibroblasts and blood-derived macrophages [19]. The gene discussed is HPGDS; the disease is breast carcinoma.