APP and Alzheimer disease: A decrease in Reelin expression in the entorhinal cortex (the first region of the brain where Aβ deposits can be observed), displayed in PDAPP transgenic mice (which carry human APP with mutations Swedish (swe) and Indiana) and in AD patients [47], could seriously affect the balance of Dab1 and Fe65 in their binding to AICD, increasing Aβ secretion.