IDE and type 2 diabetes mellitus: In 2007, the first GWAS of type 2 diabetes conducted in a French case-control cohort identified a type 2 diabetes related locus on chromosome 10q23.33, which is located in a gene cluster including the insulin-degrading enzyme (IDE), the kinesin-interacting factor 11 (KIF11), and the hematopoietically expressed homeobox (HHEX) [3].