NOTCH1 and nonpapillary renal cell carcinoma: The overall aim of this study was to determine the potential role and mechanism of Notch1 and Jagged1 in the metastasis of T1 stage renal tumors and our data showed that high-level expression of Notch signaling increased the risk of metastasis in T1 stage ccRCC by stimulating the proliferation and migration of tumor cells.