We observed a significant increase in CD45RA+FoxP3low and CD45RA−FoxP3low subsets in CD4+ T cells in patients with active SLE (2.1±0.4%; 7.2±1.0% respectively) compared with values found in healthy donors (1.3±0.2%; 4.6±0.6% respectively, p<0.05) or in patients with inactive SLE (1.1±0.1%; 5.1±0.4% respectively, p<0.05) (Fig. 1D, subpopulations Fr I and Fr III). Here, CD4 is linked to systemic lupus erythematosus.