The CD45RA+FoxP3high population was not significantly different between HD and active SLE, although it was positively correlated to the CD25+FoxP3+ subsets, suggesting that CD25+FoxP3+ may be not an exclusive marker of Treg cells in SLE, as it may be expressed in active T cells. The gene discussed is FOXP3; the disease is systemic lupus erythematosus.