In contrast, a significant increase in the mean percentage of CD25-FoxP3+ CD4+ T cells was observed in patients with active SLE (7.4±0.8%) when compared with that of normal controls (3.2±0.4%, p<0.01), or that of SLE patients with inactive disease (4.4±0.4%, p<0.05) (Fig. 1B, right), suggesting that in active SLE patients the CD4+FoxP3+ T cells are not correlated with the number of CD4+CD25+ T cells. The gene discussed is CD4; the disease is systemic lupus erythematosus.