CCND1 and hepatocellular carcinoma: In the case of hepatocellular carcinoma molecular alterations responsible for its development and progression include: 1) loss of tumor suppressors genes, as p53 and/or activation of cyclin D1, 2) activation of oncoproteins as c-myc, and 3) alterations in Wnt signaling leading to nuclear accumulation of β-catenin [10], [30].