Finally, our proteomic analysis showed a higher presence of hepatocellular carcinoma-related proteins, such as cathepsin β precursor, cathepsin D precursor, adenine phosphoribosyl transferase, L-lactate dehydrogenase, triosephosphate isomerase, inorganic pyrophosphatase or peptidyl prolyl cis-trans isomerase, in CM2 treated cells compared to CM1 treated cells. The gene discussed is CTSB; the disease is hepatocellular carcinoma.