CLU and Alzheimer disease: Although the primary role of clusterin in AD is unclear, CLU is implicated in AD by several lines of evidence, including (I) CLU mRNA and clusterin protein is increased in AD [5], [6], (ii) clusterin is a component of plaques [4], [5], [7], (iii) clusterin modulates AD-related pathways such as inflammation and apoptosis [1], [8], [9] and (iv) clusterin acts as an amyloid-beta (Aß) chaperone to alter Aß aggregation and/or clearance ([10], [11], reviewed in [4], [12], [13], [14]).