Risperidone, which blocks both 5-HT2 and D2 receptors does improve both positive and negative symptoms of schizophrenia, while ritanserin, a very potent and selective 5-HT2 receptor antagonist, showed significant improvement in Type II schizophrenics [those with primarily negative symptoms].Drugs acting on 5-HT3 receptors e.g. ondansetron have also been investigated as new anti-psychotics [7]. The gene discussed is HTR2A; the disease is schizophrenia.