IGHE and Friedreich ataxia: Experimental FA models where repeated oral challenges with OVA in systemically OVA-primed BALB/c mice led to allergic diarrhea require aberrant Th2-type responses, such as an enhanced production of IL-4, IL-5, and IL-13 by the spleen and large intestine and high levels of OVA-specific plasma IgE [14, 15].