Furthermore, our results indicate that OVA transferred through breast milk from OVA-exposed mothers during lactation induces oral tolerance, which suppresses the increases in plasma OVA-specific IgE levels and Th2 cytokine mRNA expression levels in the mucosal immune system and the augmentation of the infiltration of mucosal mast cells into the colon, thereby alleviating the development of FA. The gene discussed is IGHE; the disease is Friedreich ataxia.