One possible mechanism involved in IL-2 suppression in mesenteric lymph nodes could be associated with the differential distribution of regulatory T cells (Treg cells) among distinct lymphoid organs in infection, since IL-2 could be produced in normal levels and be sequestered by CD25highCD4+FOXP3+ cells, which have been demonstrated to be present in secondary lymphoid organs during infection [9, 57]. Here, IL2 is linked to infection.