To study the long-term effect of p27Kip1 silencing on islet graft function, batches of 200 isogeneic islets with targeting or non-targeting transduction were implanted in the subcapsular space of the left kidney of B6 mice with streptozotocin-induced diabetes, and the whole blood glucose and body weight were measured. Here, CDKN1B is linked to diabetes mellitus.