To investigate the short-term effect of p27Kip1 silencing on islet cell proliferation, batches of 50 each of targeting and non-targeting transduced islets were implanted in the subcapsular space of the left kidney of normal healthy mice and B6 mice with streptozotocin-induced diabetes; 6 days later, the grafts were removed and immunohistochemistry was performed. This evidence concerns the gene CDKN1B and diabetes mellitus.