APOE and epilepsy: These findings suggest that neurons from individuals with the APOE ε3,3 genotype are better able to mount appropriate and more liberal repair responses to the damaging hyperexcitability of epilepsy than are their APOE ε4,4 counterparts, suggesting that APOE ε3, but not APOE ε4, alleles confer resilience to host neurons no matter the type of injury.