APOE and epilepsy: Moreover, evidence of greater neuron sparing in epilepsy patients with APOE ε3,3 than APOE ε4,4 genotype may be a case in point for genetic variation favoring typical, evolutionarily old, acute phase responses [19] of neurons to adverse stimuli, which includes elevation of IL-1α, βAPP and ApoE expression [10] and protection against DNA fragmentation.