The numbers of neurons in temporal lobe tissue of our epilepsy patients who were either APOE ε3,3 or APOE ε4,4 genotype were similar, but there were striking differences in the indicators of degeneration in neurons, as neurons from patients with APOE ε3,3 were larger, appeared more normal morphologically, and had less DNA damage. This evidence concerns the gene APOE and epilepsy.