TNF and infection: The absence of obvious clinical signs correlates with: i) normal blood cell and platelet counts; ii) the lack of a recruitment of proinflammatory cells at the site of infection; iii) the presence of minimal levels of serum IL-1β, TNF-α, IL-10 and IL-6; iv) very low amounts of MCP-1 and RANTES chemokines [48,137]; and, v) the absence of synthesis and degradation of fibrinogen and coagulopathies [48].