INS and type 2 diabetes mellitus: In a very recent study, Soeda et al. [198] described an increase in insulin signaling upon neuronal mutation of SH2-containing inositol 5′-phosphatase 2 (SHIP2, a negative regulator of phosphatidylinositol 3, 4, 5-trisphosphate-mediated signals) and that SHIP2 levels were also increased in type 2 diabetes db/db mice brain.