PTGS2 and hypertensive disorder: Although no evidence has directly shown the attenuation of untransformed and bioactive PGH2 during aging or in cardiovascular pathology, likely due to instability and difficulty in measurement [25, 26, 91, 92, 95, 96], increased COX1 and COX2 associated with aging [21, 29, 42, 63, 84–86] and hypertension [63, 84, 87, 88] would be predicted to result in increases in untransformed PGH2.