Therefore, we proposed that calreticulin, a protein initially identified as an endoplasmic reticulum luminal chaperone that controls the regulation of intracellular Ca2+ homeostasis [23], could be pivotal in the downregulation of C/EBPα translation and may be one of the key regulators to explain low levels of C/EBPα proteins in BSM cells of asthma patients. The gene discussed is CEBPA; the disease is asthma.