PRRT2 and neoplasm: Importantly, natural or synthetic phorbol esters, like phorbol-12-myristate 13-acetate (PMA), a tumor promoting agent, or prostratin, a non-tumor promoting phorbol, as well as select lactones like bryostatin-1 can serve as mimetics or analogues of DAG to modulate PKC pathway activity for the induction of latent proviral expression [20–22].