FN1 and atherosclerosis: In addition, it has been implicated in angiogenesis, bone development, atherosclerosis, inflammation, and wound healing [44] by virtue of its ability to degrade several ECM macromolecules including collagens, laminins, fibronectin, aggregan, and fibronectin and to activate proMMP-2 and proMMP-13 [42, 44, 52].