Three antivascular endothelial growth factor (VEGF) therapies are currently used for the treatment of patients with wet age-related macular degeneration (AMD): pegaptanib (Macugen, Pfizer, UK), ranibizumab (Lucentis, Novartis, UK), and bevacizumab (Avastin, Roche, UK). The gene discussed is VEGFA; the disease is wet macular degeneration.