More importantly, since Tlr2−/−Tlr9−/− double knockouts display higher parasitemia than the single Tlr2−/− or Tlr9−/− mice, this work was the first to demonstrate that TLR2 and TLR9 can cooperate, and/or that a degree of redundancy exist among different TLR family members, in the control of parasite replication. This evidence concerns the gene TLR2 and parasitic infectious disease.