MARK2 and cancer: It is well known that PI3K can mediate the phosphorylation and activation of its downstream serine/threonine kinase, Akt (or PKB), participating in some important biological activities such as survival, proliferation, migration and differentiation in human cancer [33].The activation of Akt also contributes to tumorigenesis and tumor metastasis in various types of human cancer [34], [35].