Studies with human or animal tumor models implicated that malignant tumor cells themselves could secrete high levels of VEGF-C [26], and this overexpression of tumor-derived VEGF-C might play an important role in intratumorally-occurred lymphangiogenesis, which would in turn promote dissemination of tumor cells to regional lymph nodes [27]–[29]. This evidence concerns the gene VEGFC and neoplasm.