In conclusion, our findings support the hypothesis that during the process of tumor-induced lymphangiogenesis, the extra domain A of fibronectin could promote the creation of new lymphatic vessels and one of its mechanisms may be that EDA could enhance VEGF-C concentration in colorectal cancer, and the activation of the PI3K/Akt signaling pathway is involved in this upregulation. Here, FN1 is linked to neoplasm.