Given the centrality of HBx to HBV associated HCC [4], and that the HBx target, URG11 strongly stimulates hepatocellular growth and tumorigenesis [18], miRNA array analysis was conducted with HepG2X, HepG2URG11 and HepG2CAT cells to identify differentially expressed miRNAs. This evidence concerns the gene VWCE and hepatocellular carcinoma.