Additionally, plasma proteome analysis showed that chitosan increases the level of adiponectin and decreases the levels of obesity-related proteins, such as resistin, retinol-binding protein 4, TNF-α and interleukin-6 (IL-6), contributing to the anti-diabetic and anti-obesity potentials in ob/ob mice [10]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.