Moreover, although the two mouse groups did not have any differences in glucose tolerance and insulin resistance at the beginning of the experiment, the HFD-fed mice developed a significantly less glucose tolerant and more insulin resistant phenotype than the SD-fed mice after 5 months on the diet, as revealed by the IPGTT (Intraperitoneal Glucose Tolerance Test) and by the IPITT (Intraperitoneal Insulin Tolerance Test), correspondingly (Fig. S6). The gene discussed is INS; the disease is Insulin resistance.