Instead, the heavy chain variable region of PN-SIA49 results from VH3-23 gene rearrangement with the D3-3 and JH6 gene segments demonstrating that, despite the preferential usage of VH1-69 in the heterosubtypic response to influenza HA [20], an in-vivo heterosubtypic protection may be conferred also by non VH1-69 derived Abs. Here, DDX41 is linked to influenza.