HMGB1 and neoplasm: To test the serum values of HMGB1 and CEA from our collected blood sample sets, we have analyzed the 219 tumor cases according to several clinicopathologic features including age, gender, TNM stage, tumor location, size of tumor mass, status of microsatellite instability, status of recurrence, time of survival, tumor differentiation, and tumor metastasis (Table 2)