The average serum HMGB1 levels were 1.5-fold higher (P = 0.03) in colorectal cancer patients; the mean serum concentration was 58.8±126.2 ng/mL in colorectal cancer patients and 39.7±16.2 ng/mL in control subjects (Figure S2A). The gene discussed is HMGB1; the disease is colorectal cancer.